Fig. 2

Hormone concentrations in the plasma and pituitary gland of Pappa2^ko/ko and Pappa2^wt/wt mice (males and females) in adulthood. Concentrations of total IGF1 (A), IGFBP5 (B) and GH in plasma (C), and GH in pituitary gland (D) are represented as mean ± S.E.M (n = 8–10 per experimental group). Two-way ANOVA and Tukey-corrected tests: *^/***p < 0.05/0.001 versus respective wt/wt males and females; ^###p < 0.001 versus respective wt/wt and ko/ko males