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Table 4 Results of interaction tests comparing causal estimates

From: Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis

Group 1

\({\widehat{\theta }}_{1}\)

\(SE\left({\widehat{\theta }}_{1}\right)\)

Group 2

\({\widehat{\theta }}_{2}\)

\(SE\left({\widehat{\theta }}_{2}\right)\)

\(\Delta\)

\(SE(\Delta )\)

p-value

M

0.92

0.03

W

0.92

0.03

0.01

0.04

0.858

M (GLGC)

1.13

0.01

W (GLGC)

1.26

0.02

0.13

0.02

1.07 × 10–7

M—free

0.98

0.03

W—free

0.89

0.03

− 0.09

0.04

0.024

M—treated

0.59

0.06

W—treated

0.80

0.11

0.21

0.12

0.083

Treated

0.66

0.05

free

0.94

0.02

0.28

0.06

1.07 × 10–6

M—treated

0.59

0.06

M—free

0.98

0.03

0.40

0.06

7.30 × 10–10

W—treated

0.80

0.11

W—free

0.89

0.03

0.09

0.11

0.401

  1. We report and compare the results of the models with four instrumental variables using data from the UKBB. For the comparison of statin-adjusted men and women, additional data from the Global Lipids Genetics Consortium (GLGC) was available with larger sample size. The difference \(\Delta\) of effect sizes was always calculated as group 2–group 1