Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis

Table 2 Overview of \({\text{SNP}}\times {\text{sex}}\) and \({\text{SNP}}\times {\text{statin}}\) interactions significant after hierarchical FDR control

Cytoband	Candidate gene	SNP	Best subgroup	Type	\(\left\|\Delta \right\|\)	q-value
1p32.3	PCSK9	rs11591147	Free	Statin-related^a	0.080	8.77 × 10^–3
1p32.3	PCSK9	rs693668	M	Sex-related^b	0.022	2.55 × 10^–4
1p32.3	PCSK9	rs11583680	M	Statin-related^c	0.031	1.56 × 10^–2
2p24.1	APOB	rs1367117	Free	Free-specific	0.019	5.98 × 10^–3
10q21.3	JMJD1C	rs1074013	Free	Free-specific	0.014	2.73 × 10^–2
6q11.1	KHDRBS2	rs3076276	Treated	Treatment-specific	0.072	2.45 × 10^–5
7q36.1	PRKAG2	rs34924001	M—free	Male-specific	0.040	1.73 × 10^–4
7q36.1	PRKAG2	rs34924001	M—free	Free-specific	0.052	1.73 × 10^–4
10q11.21	ALOX5	rs76849715	M—free	Male-specific	0.057	2.79 × 10^–4
10q11.21	ALOX5	rs76849715	M—free	Free-specific	0.054	2.97 × 10^–3
12p12.2	SLCO1B3	rs4762806	W—free	Female-specific	0.071	1.22 × 10^–3
12q24.22	NOS1	rs4767549	M	Male-specific	0.018	2.46 × 10^–3

All 14 independent SNPs were tested for 2-way interactions. We first report significant interactions at the PCSK9 locus, then other known loci, and finally, for the novel loci identified in our meta-analysis. We only report the absolute differences of effects as the sign also depends on the choice of effect alleles. The significant interaction was denoted stratum-specific, if the SNP effect was suggestive significant (p < 1 × 10^–6) in only one of the two tested subgroups, and stratum-related, if the SNP had suggestively significant effects in both compared subgroups. For complete results, see Additional file 2: Table S6a
^aStronger effect in statin-free individuals
^bStronger effects in men
^cStronger effects in statin-treated individuals

ISSN: 2042-6410