Fig. 1

Heatmap of the log-transformed p-values of the 14 independent SNPs across all eight subgroups and of the within-PCSK9 colocalization. SNPs are sorted as in Table 1 (by novelty and chromosomal position). The horizontal dotted lines divide three groups of associations: the main hit at the PCSK9 gene locus, known loci with genes involved in lipid metabolism (all best-associated in the statin-free subgroup), and novel associations detected in other subgroups. Phenotypes are sorted by sample size (free, males, women, treated), and similarity, as the statin-combined and statin-free sexes show mostly the same effects. *Subgroup with lowest p-value per SNP. Y denotes significant interaction