Fig. 2

Sex differences in DNA mutation and copy number alterations. A Gene mutation and copy number landscape of GBM were analyzed based on sex. Genes known to be important in GBM were considered. B MutsigCV q-value data was analyzed. Turquoise represents significance in males, pink represents significance in females. The line represents the significance cutoff at a q-value of 0.1. C GISTIC heatmap was used to show the genomic copy number profiles from the GBM cohort in TCGA. The gain (red) and loss (blue) of each peak were shown. The x-axis represents the significance of the q-value. The top is the q-value of loss, the bottom is the q-value of gain. The green line represents the significance cutoff at a q-value of 0.25. D Tumor mutation burden (TMB) value was analyzed in males and females, and the p-value was calculated using the Wilcoxon test. E Aneuploidy score was analyzed in males and females, and the p-value was calculated using a t-test. F Copy number segment count value was analyzed in males and females. 10 ~ 100 k amplification (red), 100 k ~ amplification (dark red), 1 ~ 10 k deletion (sky), 10 ~ 100 k deletion (blue), 100 k ~ deletion (dark blue). G Gene mutation and significant copy number changes for the RTK/RAS/PI(3)K, p53, and cell cycle signaling pathways were shown. Red represents activating alteration; blue represents inactivating alteration. Deepening shade shows frequency. The left indicates male, and the right indicates female