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Fig. 7 | Biology of Sex Differences

Fig. 7

From: Sex-specific modulation of early life vocalization and cognition by Fmr1 gene dosage in a mouse model of Fragile X Syndrome

Fig. 7

Syntactic transition probability in female FXS pups. (A–F) The probability of transitions ‘from’ and ‘to’ a specific USV class varies among different vocalization classes in +/+ (A, B), +/- (C, D) and -/- females (E, F). (G, H) These profiles are similar among genotypes in the probability of transition “from” (G) and “to” (H) a specific class of USVs. (I) Qualitative illustration of transition probability profiles for females of various genotypes. (A–H) Data are shown as a bar graph (mean ± SEM). (A-F) The hashtag (#) refers to statistics presented in Suppl. Tables 8 and 11. (G, H) Full statistics can be found in Suppl. Tables 9 and 12. (A-H) Statistical analysis was done using Mann-Whitney U tests. (I) Arrow diagrams. Arrows indicate transition directions, with brighter colors signifying higher transition probabilities. C = Complex, DR = Downward ramp, IU = Inverted-U, UR = Upward ramp, CT = Complex trill, S = Short, SD = Step Down, F = Flat, SU = Step up, and T = Trill. Sample size: (A-I) +/+ females N = 7, +/- females N = 13 and -/- females N = 6

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