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Fig. 6 | Biology of Sex Differences

Fig. 6

From: Sex-specific modulation of early life vocalization and cognition by Fmr1 gene dosage in a mouse model of Fragile X Syndrome

Fig. 6

Syntactic transition probability in male FXS pups. (A – D) The probability of transitions ‘from’ and ‘to’ a specific USV class varies among different vocalization classes in +/y (A, B) and -/y (C, D) males. (E, F) Transition probabilities differ ‘from’ a specific USV class (E), but not ‘to’ a specific class (F). (G) Qualitative illustration of transition probability profiles for males of various genotypes. (A-F) Data are shown as a bar graph (mean ± SEM). The p-values < 0.05 are indicated with an asterisk (*) and the full statistics can be found in Suppl. Tables 9 and 12. The hashtag (#) refers to statistics presented in Suppl. Tables 7 and 10. Statistical analysis was done using Mann-Whitney U tests. (G) Arrow diagrams. Arrows indicate transition directions, with brighter colors signifying higher transition probabilities. C = Complex, DR = Downward ramp, IU = Inverted-U, UR = Upward ramp, CT = Complex trill, S = Short, SD = Step Down, F = Flat, SU = Step up, and T = Trill. Sample sizes: (A-G) +/y males N = 9 and -/y males N = 14

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