Table 1 Estrus and non-estrus phase related to alcohol-related behavioral assessment
From: Different mechanisms underlie compulsive alcohol self-administration in male and female rats
Behavior | Estrus Mean ± SEM | Non-estrus Mean ± SEM | Subject (N) estrus | Subject (N) non-estrus | Phase effect F-value, p value; η2 |
|---|---|---|---|---|---|
Alcohol self-administration (reinforcers) | 14.81 (± 7.5) | 15.05 (± 5.7) | 53 | 107 | F1,158 = 0.81, p = 0.57 |
Motivation (break points) | 11.2 (± 4.3) | 13.9 (± 6.12) | 12 | 20 | F1,30 = 1.4, p = 0.186 |
Footshock-punished alcohol self-administration (reinforcers) | 6.3 (± 7.4) | 5.6 (± 6.3) | 82 | 76 | F1,156 = 0.59, p = 0.6 |
Resistance to quinine-induced alcohol adulteration (reinforcers) | 9.3 (± 3.7) | 11.4 (± 5.1) | 53 | 43 | F1,94 = 2.34, *p < 0.05; η2 < 0.05 |
Temporal discounting of alcohol reward (reinforcers) | 5.7 (± 1.8) | 6.5 (± 2.9) | 38 | 26 | T1,162 = 1.34, p = 0.2 |
Anxiety (% time in open arms) | 65.5 (± 16.6) | 68.1 (± 14.8) | 14 | 18 | T1,130 = 0.47, p = 0.6 |
Pain sensitivity (mA) (shock threshold) | 0.2 (± 0.03) | 0.2 (± 0.05) | 14 | 17 | T1,29 = 0.47, p = 0.6 |