Table 3 Gene transcripts normalized by DMF in CUS-exposed female rats (absolute ΔLogFC > 0.3)
GENE | CUS RESPONSE | Encoded protein function |
|---|---|---|
Tpt1 | ↑ | Translationally-controlled tumor protein 1; Diverse functions including DNA damage repair, autophagy, protein degradation; antioxidant properties and implicated in immune responses |
Cnppd1 | ↑ | Cyclin Pas1/PHO80 domain containing 1; function in brain unknown; predicted to be involved in the regulation of cyclin dependent kinase activity |
Grm2 | ↑ | Metabotropic glutamate receptor 2; activation is anti-inflammatory; implicated in depression, stress resilience and vulnerability, anxiety |
Zfp46 | ↓ | Zinc finger protein 46, transcription factor; biological functional pathways unknown |
Olr522 | ↓ | Encodes for an olfactory receptor; specific function unknown although several functions for non-chemosensory regions in brain have been characterized |
Dcn | ↓ | Decorin; extracellular matrix proteoglycan; plays a key role in inflammatory and autoimmune disorders |