Table 2 Gene transcripts normalized by DMF in CUS-exposed male rats (absolute ΔLogFC > 0.3)
GENE | CUS RESPONSE | Encoded protein function |
|---|---|---|
Nnat | ↑ | Neuronatin; ER membrane protein and linked to ER stress; involved in inflammation, calcium signalling, and glucose signalling |
Tacr3 | ↑ | Tachykinin/neurokinin 3 receptor; promotes acetylcholine release; involved in learning and memory, implicated in anxiety and depression |
Arhgdib | ↑ | Rho GDP dissociation inhibitor beta; involved in immune and inflammatory responses |
Lyz2 | ↑ | Lysozyme 2; marker of microglial activation; linked to immune and inflammatory responses |
Gpx3 | ↑ | Glutathione peroxidase 3; known target gene of Nrf2; selenoprotein of the glutathione peroxidase family; antioxidant enzyme |
S100a11 | ↑ | Calgizarrin; calcium binding protein; implicated in pro-inflammatory processes |
Rpl30 | ↓ | Ribosomal protein L30; component of 60S subunit |
Lce1d | ↓ | Late cornified envelope 1d; known target gene of Nrf2 in keratinocytes; function in brain unknown |