Nrf2 activation rescues stress-induced depression-like behaviour and inflammatory responses in male but not female rats

Table 1 Gene transcripts altered in both male and female rats following CUS

Male	Female	Gene	Encoded protein function
↑	↑	Cnppd1	Cyclin Pas1/PHO80 domain containing 1; function in brain unknown; predicted to be involved in the regulation of cyclin dependent kinase activity
↑	↓	Dusp12	Dual specificity phosphatase 12; MAPK phosphatase; protective against endothelial cell inflammation and oxidative stress
↓	↓	Chchd2	Coiled-Coil-Helix-Coiled-Coil-Helix domain containing 2; mediator of oxidative phosphorylation and repressor of the mitochondrial stress response; implicated in Parkinson’s disease
↑	↓	Arhgdib	Rho GDP dissociation inhibitor beta; involved in immune and inflammatory responses
↓	↓	Opalin	Oligodendrocytic myelin paranodal and inner loop protein; transmembrane sialylglycoprotein; enriched in oligodendrocytes and involved in myelin stabilization
↓	↓	Cyp2J10	Cytochrome p450 enzyme; implicated in antidepressant responses

ISSN: 2042-6410