Fig. 6
Lipidomics data visualized with LINEX2. Global lipid network visualization for IF (A) and IM (B) comparisons. C–H Magnified network views of specific lipids for IF (C–E) and IM (F–H). IF impact of AUD in females, IM impact of AUD in males. Red spherical nodes represent lipids with a positive LFC (higher abundance in AUD), whereas blue nodes indicate a negative LFC (higher abundance in control). The spherical node sizes indicate the −log10 FDR corrected p-values of lipid species between AUD and control females and males (a larger node size represents a higher level of statistical significance). Edges are colored by correlation changes for lipids from AUD patients to healthy individuals: negative to positive (significant correlation in both groups, < 0 in AUD and > 0 in control), positive to negative (significant correlation in both groups, > 0 in AUD and < 0 in control), significant to insignificant (significant correlation in AUD, insignificant in control), unchanged significant (significant in both groups, either both > 0 or both < 0), insignificant (uncorrelated in both groups), and insignificant to significant (insignificant in AUD, significant in control). Lipid network and other LINEX2 analyses can be explored in an interactive version, available as in the web-platform http://bioinfo.cipf.es/sal-chronics/lipid_net.html