Sex-based disparities in DNA methylation and gene expression in late-gestation mouse placentas

Table 3 Top autosomal DMRs

Gene symbol	Chromosome	Annotation	Change in methylation
Increased in male placentas
Ube2k	5	Promoter-TSS	− 36.70
Tiam2	17	Intron	− 35.97
Map1b	13	Intron	− 35.44
Ccdc116	16	3′ UTR	− 35.31
Pygb	2	Intron	− 35.00
Ccdc60	5	Intron	− 34.52
Snord116l2	7	Intron	− 33.61
Lrpprc	17	Intron	− 33.26
Jdp2	12	TTS	− 32.69
Col6a3	1	Intron	− 32.53
Slc36a3	11	Exon	− 31.99
Ddr1	17	Intron	− 30.82
Mrpl45	11	3′ UTR	− 29.56
Alg6	4	Intron	− 29.31
Mir218-2	11	Intron	− 28.90
Trhr2	8	Intron	− 28.86
Tssc4	7	Exon	− 28.82
Krtdap	7	TTS	− 27.75
Gip	11	Exon	− 27.73
Nuak1	10	Intron	− 27.59
Increased in female placentas
Proz	8	TTS	38.15
Tmem267	13	Promoter-TSS	36.91
Cdk5rap1	2	Intron	34.71
Stam2	2	Intron	34.66
Cdk5rap1	2	Exon	33.96
Clip4	17	Intron	33.56
Cacng3	7	Promoter-TSS	32.84
Tmem267	13	Promoter-TSS	32.32
Pbx1	1	Intron	32.25
Adamts2	11	Intron	30.96
Cdk5rap1	2	Intron	30.28
Dennd1c	17	Promoter-TSS	29.27
Tmem267	13	Promoter-TSS	29.02
Tmem267	13	Promoter-TSS	27.87
Mbp	18	Intron	27.65
Ppox	1	TTS	27.44
Phf19	2	Intron	25.47
Bcl2l11	2	Intron	25.26
Nckap5	1	Intron	25.05
Cdk5rap1	2	Intron	25.01

ISSN: 2042-6410