Fig. 2

DMRs are present throughout the genomes of late-gestation mouse placentas. A Schematic of the analyzed tiles in autosomes (left) and X chromosomes (right). DMRs exhibiting higher methylation levels in male or female placentas are indicated. B DNA methylation levels of autosomal (left) and X chromosome (right) DMRs in male and female E18.5 placentas. Samples are clustered by methylation level. C DMRs located on autosomes (left) and X chromosomes (right). Dark colors represent regions with ≥ 10% increased methylation in female placentas (higher in female), while light colors represent regions with ≥ 10% decreased methylation in female placentas (higher in male). D The proportions of autosomal and X chromosomal DMRs that caused DNA methylation level changes of various magnitudes. E The top five pathways enriched in autosomal (left) and X chromosomal (right) genes with DMRs that result in higher methylation levels in male (top) and female (bottom) placentas. F DNA methylation levels of autosomal (left) and X chromosomal (right) DMRs associated with the top five enriched pathways in male and female placentas