Table 1 Total exploration time (s) accumulated during NOR and NOL testing phases

NOR

 \(\text{ER}\alpha\)^+/+_sham+VC

81 ± 7

75 ± 8

0.2

0.56

 \(\text{ER}\alpha\)^+/+_HI+VC

78 ± 8

79 ± 6

0

0.91

 \(\text{ER}\alpha\)^+/+_HI+DHF

91 ± 14

100 ± 10

0.2

0.62

 \(\text{ER}\alpha\)^−/−_sham+VC

66 ± 13

60 ± 19

0.2

0.79

 \(\text{ER}\alpha\)^−/−_HI+VC

88 ± 16

73 ± 21

0.3

0.63

\(\text{ER}\alpha\)^−/−_HI+DHF

90 ± 10

85 ± 14

0.2

0.78

NOL

 \(\text{ER}\alpha\)^+/+_sham+VC

70 ± 5

67 ± 5

0.2

0.64

 \(\text{ER}\alpha\)^+/+_HI+VC

78 ± 6

58 ± 6

1

0.032

 \(\text{ER}\alpha\)^+/+_HI+DHF

74 ± 15

80 ± 10

0.2

0.71

\(\text{ER}\alpha\)^−/−_sham+VC

51 ± 9

51 ± 8

0

0.99

\(\text{ER}\alpha\)^−/−_HI+VC

58 ± 5

92 ± 25

1.3

0.13

 \(\text{ER}\alpha\)^−/−_HI+DHF

78 ± 13

65 ± 9

0.6

0.42