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Fig. 3 | Biology of Sex Differences

Fig. 3

From: Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell

Fig. 3

Sex differences in entries made and time spent in the acquisition zone during acquisition. A At all stimulation frequencies, the total number of entries into the acquisition zone were significantly greater than the average number of entries into the inactive zones (indicated by asterisks). There were also significant differences in the number of entries made into the active zone between 10 and 20 Hz, 10 Hz and 30 Hz, and 20 Hz and 30 Hz (denoted by different letters above each bar). At 30 Hz, there were significant differences between the sexes, shown as the colored bar. B Males entered the acquisition zone significantly more than the inactive zones only at 30 Hz. Males displayed no significant differences across frequencies in the number of entries into the acquisition zone. C In females, the total time spent in the acquisition zone was greater than the time spent in the inactive zones across all frequencies. There were also significant differences in the time spent in the acquisition zone between 10 and 20 Hz, and between 10 and 30 Hz. There were sex differences in the amount of time spent in the acquisition zone at 20 Hz and 30 Hz. D Males spent more total time in the acquisition zone versus the inactive zones at all frequencies. However, there were no significant differences in the time spent in the acquisition zone between any of the stimulation frequencies. Representative track plots illustrate travel throughout the duration of the 30-Hz acquisition trial for E females and F males. The acquisition zone is indicated by the blue square. Data presented as mean ± SEM

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