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Fig. 5 | Biology of Sex Differences

Fig. 5

From: Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice

Fig. 5

Alcohol consumption is correlated with water consumption and EtOH preference in males but not females. A–C R values reported from linear regressions for correlations between alcohol consumption versus total volume intake, water consumption, and EtOH preference. A At the 2-h timepoint, there was a positive correlation between alcohol consumption and total volume in the 10% EtOH males and 20% EtOH females, and a trend towards a positive correlation between alcohol consumption and preference in the 10% EtOH males. B At the 4-h timepoint, alcohol consumption was positively correlated with total volume intake for both sexes in both the 20% and 10% EtOH cohorts, while there was a trend towards a negative correlation between alcohol and water consumption in the 10% EtOH male group and positive correlation between alcohol consumption and EtOH preference in this group only. C At the 24-h timepoint, alcohol consumption and total volume intake was positively correlated in the 20% EtOH female and 10% EtOH male groups. Alcohol and water consumption were negatively correlated while alcohol consumption and EtOH preference were positively correlated in the 10% EtOH male cohort only, with a trend towards a positive correlation between alcohol and EtOH preference in the 20% EtOH male group. *P < 0.05, **P < 0.01, ***P < 0.001 for correlations between alcohol consumption and total volume intake, EtOH preference, or water consumed at 2, 4 and 24-h timepoints

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