Fig. 3

Sex differences in the antidepressant-like effects of letrozole. A Repeated effect of letrozole (1 h post-8 days of treatment) on testosterone levels. Data represent mean ± SEM of testosterone levels (ng/ml). B Acute (1 h post-8 days of treatment) and C repeated (1-day post-8 days of treatment) effects exerted by letrozole exposure in male and female rats in the forced-swim test (FST). Data represent mean ± SEM of the time spent (s) immobile, climbing, or swimming. A-C Individual values are shown for each rat (symbols). Two-way ANOVAs (independent variables: sex and treatment) were performed and results are shown in Additional file 1: Table S1. ^###p < 0.001 and ^##p < 0.01 when comparing female vs. male rats (effect of Sex). **p < 0.01 and *p < 0.05 vs. same-sex vehicle-treated rats. Veh vehicle, LTZ letrozole