Fig. 5
From: Endothelin mediates sex-differences in acclimation to high salt diet in rats
Dual ET receptor antagonism modulated Na+ intake and excretion in a sex-dependent manner. Na+ intake (A) and UNaV (B) in male and female rats fed a NS or a HS diet. Rats were either treated with or without the dual ET receptor antagonist (A-182086, 10 mg/kg/day). Na+ excretion was measured in urine collected over 24 h and expressed as a percent of Na+ intake. N = 7 per group. Two-way ANOVA with post hoc Sidak’s test. P values < 0.05 from post hoc test are displayed on graph. Endothelin receptor (ET), high salt (HS), normal salt (NS), sodium (Na+), and urinary sodium excretion (UNaV)