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Table 2 Association of plaque skewing with plaque characteristics

From: X chromosome inactivation skewing is common in advanced carotid atherosclerotic lesions in females and predicts secondary peripheral artery events

 

XCI skewing

Odds ratio [95% CI]

β [95% CI]

P value

Fat content (> 10%)

Dichotomous (Non-skewed)

(1.0) ref.

–

–

Dichotomous (Skewed)

0.87 [0.45 to 1.71]

–

0.69

*Continuously

0.96 [0.71 to 1.31]

–

0.82

Fat content (> 40%)

Dichotomous (Non-skewed)

(1.0) ref.

–

–

Dichotomous (Skewed)

1.41 [0.64 to 3.22]

–

0.39

*Continuously

1.08 [0.74 to 1.54]

–

0.67

Calcification (major)

Dichotomous (Non-skewed)

(1.0) ref.

–

–

Dichotomous (Skewed)

1.37 [0.71 to 2.68]

–

0.35

*Continuously

1.08 [0.80 to 1.48]

–

0.60

Collagen (major)

Dichotomous (Non-skewed)

(1.0) ref.

–

–

Dichotomous (Skewed)

0.80 [0.34 to 1.88]

–

0.61

*Continuously

0.96 [0.66 to 1.42]

–

0.82

Plaque Hemorrhage (major)

Dichotomous (Non-skewed)

(1.0) ref.

–

–

Dichotomous (Skewed)

1.50 [0.79 to 2.87]

–

0.22

*Continuously

1.44 [1.06 to 1.98]

–

0.02

Macrophage (major)

Dichotomous (Non-skewed)

(1.0) ref.

–

–

Dichotomous (Skewed)

0.77 [0.41 to 1.45]

–

0.42

*Continuously

1.03 [0.77 to 1.39]

–

0.80

Smooth muscle cells (major)

Dichotomous (Non-skewed)

(1.0) ref.

–

–

Dichotomous (Skewed)

0.98 [0.46 to 2.08]

–

0.96

*Continuously

0.92 [0.66 to 1.30]

–

0.66

**Neo-vessels (major)

Dichotomous (Non-skewed)

(1.0) ref.

–

–

Dichotomous (Skewed)

0.88 [0.44 to 1.77]

–

0.72

*Continuously

0.93 [0.68 to 1.28]

–

0.62

***Glycophorin (increase of plaque area)

Dichotomous (Non-skewed)

–

(1.0) ref.

–

Dichotomous (Skewed)

–

0.09 [-0.26 to 0.45]

0.60

*Continuously

–

0.02 [-0.13 to 0.18]

0.77

  1. *Calculated for 10 points percentage of XCI skewing. Data transformed with bestNormalize package in R: **Binarize technique; ***The Ordered Quantile Normalization technique