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Table 1 Baseline characteristics of patients with and without XCI skewing in plaque

From: X chromosome inactivation skewing is common in advanced carotid atherosclerotic lesions in females and predicts secondary peripheral artery events

XCI skewing

Overall

No Skewed

Skewed

P value

N (%)

154 (100%)

78 (50.6)

76 (49.4)

–

Age in years (mean, SD)

66 (9)

66 (9)

67 (9)

0.40

BMI (median, IQR)

26 [23, 28]

26 [23, 28]

25 [23, 27]

0.26

Current smoker, yes (%)

71 (47)

40 (53)

31 (41)

0.22

Diabetes mellitus, yes (%)

29 (19)

15 (19)

14 (18)

1.00

Hypertension, yes (%)

135 (88)

71 (91)

64 (84)

0.30

Hypercholesterolemia, yes (%)

105 (70)

51 (67)

54 (72)

0.63

History of coronary artery disease (%)

40 (26)

18 (23)

22 (29)

0.52

History of PAOD (%)

50 (32)

22 (28)

28 (37)

0.33

Use of antiplatelet therapy (%)

144 (94)

71 (91)

73 (96)

0.35

Use of lipid-lowering drugs (%)

119 (77)

58 (74)

61 (80)

0.50

GFR (MDRD) mL/min per 1.73 m2 (mean, SD)

70 (20)

69 (20)

71 (19)

0.41

LDL in mg/dL (median, IQR)

111 [82, 145]

109 [80, 144]

111 [82, 144]

0.90

HDL in mg/dL (median, IQR)

46 [37, 55]

45 [37, 55]

46 [37, 60]

0.80

Total cholesterol in mg/dL (median, IQR)

189 [147, 228]

185 [147, 226]

203 [147, 230]

0.78

Triglyceride levels in mg/dL (median, IQR)

127 [94, 189]

127 [96, 187]

129 [89, 197]

0.76

Presenting symptoms (%)

0.25

Asymptomatic

25 (18)

15 (21)

10 (16)

 

Transient Ischemic Attack (TIA)

77 (57)

36 (50)

41 (64)

 

Stroke

34 (25)

21 (29)

13 (20)

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