Fig. 2

DKC1 expression is associated with overall and progression-free survival (OS and PFS) in female but not male patients with ccRCC. The analysis was performed on 530 patients in the TCGA ccRCC cohort. Patients were classified into DKC1-low and high groups using median DKC1 mRNA levels in tumors as a cutoff point. A Kaplan–Meier survival analyses of 530 ccRCC patients based on DKC1 levels (both sexes). Left: OS and right: PFS. B Kaplan–Meier survival analyses of 530 ccRCC patients based on sex. Left: OS and right: PFS. C Univariate (left) and multivariate (right) COX regression analyses based on age, sex, stages, grades and DKC1 expression. D Significant differences in OS and PFS between DKC1-low and high groups in female ccRCC patients. E Lack of association of DKC1 expression with OS or PFS in male ccRCC patients. F DKC1 as an independent prognostic factor as assessed using univariate (left) and multivariate (right) COX regression analyses. G Univariate COX regression analyses of DKC1 expression with survival association in male ccRCC patients. Log-rank test was for A, B, D and E, while Likelihood ratio test was for Cox analyses in C, F and G