Fig. 1

DKC1 and TERC expression is upregulated in ccRCC tumors. A Enhanced DKC1 protein expression in ccRCC tumors. The DKC1 expression data were obtained from Clinical Proteomic Tumor Analysis Consortium (CPTAC) (http://ualcan.path.uab.edu/index.html). Multiplexed quantitative mass spectrometry-based proteomic targeted assays were performed on 84 NTs and 110 ccRCC tumors from the CPTAC cohort. B Upregulation of DKC1 expression in primary ccRCC tumors as determined using RNA sequencing. Tumors and matched NT tissues from 10 ccRCC patients were subject to the transcriptomic analyses. DKC1 mRNA levels were expressed as PKMT. (C and D) Upregulation of both DKC1 and TERC expression in ccRCC tumors. Tumors and matched NT tissues from the additional cohort of 10 ccRCC patients were analyzed for their DKC1 and TERC transcripts using qPCR assay. A and B were analyzed using Wilcox sum test, while C and D were analyzed using Student T test