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Table 2 Maternal cardiac data in reduced uterine perfusion pressure rat model

From: Characterisation of cardiac health in the reduced uterine perfusion pressure model and a 3D cardiac spheroid model, of preeclampsia

 

Sham (n ≥ 6)

RUPP (n ≥ 4)

p value

Maternal body weight (before surgery), g

338.6 ± 17.5

379.5 ± 4.87

0.084

Maternal heart weight, g

1.02 ± 0.05

1.22 ± 0.01

0.008**

Heart: Body weight, %

0.304 ± 0.01

0.323 ± 0.005

0.303

Embryo resorption (%)

2.38 ± 1.51

11.22 ± 3.06

0.04*

Embryo weight, g

1.68 ± 0.025

1.61 ± 0.02

0.04

Placental weight, g

0.41 ± 0.009

0.39 ± 0.006

0.047

Heart rate, bpm

369.3 ± 4.8

398.8 ± 3.7

0.0006***

Systolic BP, mmHg

112.6 ± 1.3

127.8 ± 1.9

< 0.0001***

Diastolic BP, mmHg

87.6 ± 1.7

104.0 ± 1.8

< 0.0001***

MABP, mmHg

100.9 ± 1.5

116.7 ± 1.7

< 0.0001***

Stroke volume, μl

215.0 ± 4.326

230.0 ± 13.26

0.304

Cardiac output, mL/min

79 ± 3

85 ± 5

0.067

Ejection fraction, %

82 ± 2

78 ± 2

0.233

Fractional shortening, %

52 ± 2

49 ± 2

0.236

Corrected LV mass, mg

600 ± 14

706 ± 68

0.037*

LV anterior wall systolic, mm

2.9 ± 0.12

2.9 ± 0.11

0.672

LV anterior wall diastolic, mm

1.5 ± 0.04

1.8 ± 0.17

0.152

LV posterior wall systolic, mm

2.8 ± 0.14

2.9 ± 0.09

0.303

LV posterior wall diastolic, mm

1.6 ± 0.05

1.6 ± 0.11

0.994

  1. BP, blood pressure; LV, left ventricular, MABP, mean arterial blood pressure; RUPP, reduced uterine perfusion pressure
  2. Unpaired Student’s t-test or Mann-Whitney test depending on data distribution; *p < 0.05, ***p < 0.001