From: Sex differences in soluble prorenin receptor in patients with type 2 diabetes
Variables | Total participants | Men | Women | ||||||
---|---|---|---|---|---|---|---|---|---|
 | Control | Type 2 diabetes | P value | Control | Type 2 diabetes | P value | Control | Type 2 diabetes | P value |
Plasma | |||||||||
 sPRR (ng/mL) | 16.5 (15.8–17) | 19.2 (17–21)* | 0.001 | 18 (16.5–19) | 17 (16–20) | 0.87 | 15 (14.8–16) †| 20 (18–22)‡ | †0.05 ‡0.001 |
 Renin activity (ng Ang-I /mL/h) | 3.2 (2.7–3.8) | 12 (10–14)* | 0.001 | 3.5 (2.5–4.5) | 9.8 (6.4–13.3)† ‡ ** | †0.001 ‡0.001 **0.05 | 3.0 (2.3–3.7) | 13 (11–15.6)† ‡ | †0.001 ‡0.001 |
Urine | |||||||||
 sPRR/uCr (ng/mg) | 1.6 (1.3–1.8) | 0.8 (0.6–1)* | 0.001 | 1.8 (1.4–2.4) | 0.6 (0.4–0.8)† ‡ | †0.001 ‡0.05 | 1.3 (1–1.7) | 1.0 (0.75–1.3) †| †0.001 |
 Renin activity (ng Ang-I /mL/h) | 27 (21–33) | 99 (77–120)* | 0.001 | 27 (16.5–37.4) | 125 (82–168)† ‡ ** | †0.001 ‡0.001 **0.05 | 27 (20–34) | 84 (60–108)† ‡ | †0.001 ‡0.001 |
 Prorenin/uCr (ng/g) | 141 (109–173) | 302 (232–371)* | 0.01 | 128 (91–165) | 362 (215–508)† ‡ | †0.01 ‡0.05 | 153 (103–204) | 273 (199–348)†| †0.01 |
 AGT/uCr (μg/g) | 16 (13–19) | 25 (17–32)* | 0.02 | 15 (11–20) | 30 (17–42)† ‡ | †0.05 ‡0.05 | 16 (12–20) | 21 (11–20) | 0.52 |
 TGF-β1/uCr (pg/mg) | 18 (14–22) | 31 (24–38)* | 0.001 | 16 (11–21) | 33 (20–45)†| †0.05 | 19 (13–25) | 31 (23–39)†| †0.05 |