Acute kidney injury is more common in men than women after accounting for socioeconomic status, ethnicity, alcohol intake and smoking history

Table 5 Stepwise Cox regression modelled analysis for the association of male sex with all-cause mortality after acute kidney injury occurrence during the 30-day and the 6-month follow-up periods in the total studied population

	30-day all-cause mortality after AKI		6-month all-cause mortality after AKI		1-year all-cause mortality after AKI		48-month all-cause mortality after AKI		Patients included in the model
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	Patients included in the model
Model 1	0.996, 0.384–2.582	0.99	2.083, 0.199–3.619	0.009	2.007, 1.252–3.216	0.004	1.334, 0.950–1.872	0.10	3534
Model 2	1.005, 0.387–2.606	0.99	2.159, 1.241–3.754	0.006	2.120, 1.321–3.402	0.002	1.442, 1.026–2.028	0.04	3534
Model 3	0.957, 0.369–2.482	0.93	2.003, 1.153–3.480	0.01	1.994, 1.243–3.200	0.004	1.351, 0.961–1.899	0.08	3534
Model 4	0.820, 0.307–2.194	0.69	1.996, 1.147–3.474	0.02	2.029, 1.250–3.293	0.004	1.257, 0.882–1.792	0.21	3204
Model 5	0.697, 0.242–2.006	0.50	1.521, 0.817–2.829	0.19	1.400, 0.821–2.389	0.22	0.978, 0.652–1.468	0.92	2290
Model 6	0.456, 0.151–1.376	0.16	1.405, 0.747–2.642	0.29	1.442, 0.806–2.578	0.22	1.032, 0.676–1.575	0.88	2060

AKI, acute kidney injury; BMI, body mass index; CI, confidence intervals; eGFR, estimated glomerular filtration rate; HR, hazard ratio; OR, odds ratio; Model 1, unadjusted; Model 2, adjusted for age; Model 3, adjusted for age and eGFR; Model 4, adjusted for age, eGFR, indices of deprivation, smoking, alcohol consumption and ethnicity; Model 5, adjusted for age, eGFR, indices of deprivation, smoking, alcohol consumption, ethnicity, BMI, diabetes, hypertension, coronary heart disease, stroke, peripheral vascular disease, heart failure, renal disease, liver disease, pulmonary disease and malignancy; Model 6, adjusted for age, eGFR, indices of deprivation, smoking, alcohol consumption, ethnicity, BMI, diabetes, hypertension, coronary heart disease, stroke, peripheral vascular disease, heart failure, renal disease, liver disease, pulmonary disease, malignancy, antihypertensive medication intake, statin intake, sodium, potassium and haemoglobin levels

ISSN: 2042-6410