Fig. 1

Octave band noise exposure at 101 dB SPL causes PTS in 10-week-old B6CBAF1/J mice. Hearing thresholds were compared between baseline, 24 h, 8 days, and 15 days post-noise exposure. At 24 h post-noise, significant compound threshold shifts are seen across all frequencies tested. Significant permanent threshold shifts are also detected at all frequencies tested at 8 and 15 days post-noise exposure. (**p < 0.01; **** p < 0.0001; ns non-significant)